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Progest-Avail™ is a natural topical progesterone serum providing 20 mg
of bioidentical progesterone in each 1 ml serving. This highly
bioavailable progesterone serum contains just four ingredients:
micronized USP progesterone, dimethyl isosorbide, caprylic/capric
triglyceride (from coconut), and vitamin E. This product is free of
parabens, mineral oil, and petroleum.
Progest-Avail™ consists of
a super-micronized form of natural progesterone in a proprietary
triglyceride carrier that facilitates better progesterone absorption
than conventional creams. This serum also contains a natural sugar-based
complex (dimethyl isosorbide) which increases progesterone solubility
and facilitates proper penetration through skin at an efficient rate.
Additionally, this compound helps preserve the potency of the
progesterone, in contrast to water-based products, which are susceptible
to reductions in potency of as much as 30% or more within the first
60-90 days of manufacturing due to hydrolysis of the active components.
Menopausal and Post-Menopausal Women
The natural decline in progesterone levels that occur with aging may result in hormone imbalances producing hot flashes,
mood swings, urinary incontinence, hair loss, vaginal dryness, poor concentration, uterine fibroids, loss of libido, and an
overall decline in health and quality of life. Data suggest that mean serum progesterone (and estradiol) concentrations
are significantly lower among menopausal women reporting hot flashes compared to those not reporting hot flashes,
and that higher levels of these hormones are associated with decreased odds of hot flashes.9 Micronized progesterone
supplementation has been shown to significantly decrease moderate to severe vasomotor symptoms compared to placebo
in early postmenopausal women, and does not cause a rebound increase in occurrence when treatment is stopped.10 There
may also be a role for transdermal progesterone as a hormone therapy for osteoarthritis, owing to its anti-inflammatory
actions and potential beneficial effects on bone remodeling and maintenance of healthy cartilage.11
Suggested Use:
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Apply 1-2 times per day to smooth skin areas, such as wrists, inner arms or thighs, throat, neck, abdomen or chest, or
as directed by a health care practitioner.
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For optimal use, rotate the areas of application.
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Menstruating women: Apply 1 ml of Progest-Avail™ once or twice per day on days 14 through 27 of the menstrual
cycle, or as directed by a health care professional.
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Menopausal and post-menopausal women: Apply 1 ml of Progest-Avail™ once or twice per day for 25 consecutive
days, followed by a 5-day break, or as directed by a health care professional.
Note: Monitor patients’ sex hormone levels regularly to guide dosing and treatment strategies.
References
9. Gallicchio L, Miller SR, Kiefer J, Greene T, Zacur HA, Flaws JA. Risk factors for hot flashes among women undergoing the menopausal transition: baseline results from the Midlife Women’s Health Study. Menopause (New York, NY). 2015;22(10):1098-1107. doi:10.1097/GME.0000000000000434.
10. Prior JC, Hitchcock CL. Progesterone for hot flush and night sweat treatment--effectiveness for severe vasomotor symptoms and lack of withdrawal rebound. Gynecol Endocrinol. 2012 Oct;28 Suppl 2:7-11.
11. Wardhana et al. Transdermal bio-identical progesterone cream as hormonal treatment for osteoarthritis. Acta Med Indones. 2013 Jul;45(3):224-32.
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