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Price: $41.91



Progest-Avail™ is a natural topical progesterone serum providing 20 mg of bioidentical progesterone in each 1 ml serving. This highly bioavailable progesterone serum contains just four ingredients: micronized USP progesterone, dimethyl isosorbide, caprylic/capric triglyceride (from coconut), and vitamin E. This product is free of parabens, mineral oil, and petroleum.

Progest-Avail™ consists of a super-micronized form of natural progesterone in a proprietary triglyceride carrier that facilitates better progesterone absorption than conventional creams. This serum also contains a natural sugar-based complex (dimethyl isosorbide) which increases progesterone solubility and facilitates proper penetration through skin at an efficient rate. Additionally, this compound helps preserve the potency of the progesterone, in contrast to water-based products, which are susceptible to reductions in potency of as much as 30% or more within the first 60-90 days of manufacturing due to hydrolysis of the active components.

Menopausal and Post-Menopausal Women

The natural decline in progesterone levels that occur with aging may result in hormone imbalances producing hot flashes, mood swings, urinary incontinence, hair loss, vaginal dryness, poor concentration, uterine fibroids, loss of libido, and an overall decline in health and quality of life. Data suggest that mean serum progesterone (and estradiol) concentrations are significantly lower among menopausal women reporting hot flashes compared to those not reporting hot flashes, and that higher levels of these hormones are associated with decreased odds of hot flashes.9 Micronized progesterone supplementation has been shown to significantly decrease moderate to severe vasomotor symptoms compared to placebo in early postmenopausal women, and does not cause a rebound increase in occurrence when treatment is stopped.10 There may also be a role for transdermal progesterone as a hormone therapy for osteoarthritis, owing to its anti-inflammatory actions and potential beneficial effects on bone remodeling and maintenance of healthy cartilage.11

Suggested Use:

  • Apply 1-2 times per day to smooth skin areas, such as wrists, inner arms or thighs, throat, neck, abdomen or chest, or as directed by a health care practitioner.

  • For optimal use, rotate the areas of application.

  • Menstruating women: Apply 1 ml of Progest-Avail™ once or twice per day on days 14 through 27 of the menstrual cycle, or as directed by a health care professional.

  • Menopausal and post-menopausal women: Apply 1 ml of Progest-Avail™ once or twice per day for 25 consecutive days, followed by a 5-day break, or as directed by a health care professional.

    Note: Monitor patients’ sex hormone levels regularly to guide dosing and treatment strategies.

    Gallicchio L, Miller SR, Kiefer J, Greene T, Zacur HA, Flaws JA. Risk factors for hot flashes among women undergoing the menopausal transition: baseline results from the Midlife Women’s Health Study. Menopause (New York, NY). 2015;22(10):1098-1107. doi:10.1097/GME.0000000000000434.
    Prior JC, Hitchcock CL. Progesterone for hot flush and night sweat treatment--effectiveness for severe vasomotor symptoms and lack of withdrawal rebound. Gynecol Endocrinol. 2012 Oct;28 Suppl 2:7-11.
    Wardhana et al. Transdermal bio-identical progesterone cream as hormonal treatment for osteoarthritis. Acta Med Indones. 2013 Jul;45(3):224-32.

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