What is COMT?

Enzyme that catalyzes the production or elimination of important molecules such as:

• Dopamine
• Epinephrine
• Norepinephrine
• Estrogens
• Various chemicals (endocrine disruptors)
• Toxins

Problems associated with abnormal COMT:

• increased risk of nervousness/anxiety (especially when history of childhood trauma and PTSD)
• acute or chronic stress
• can compromise working memory, decision-making ability, or mood
• cognitive instability, e.g., ability to focus
• possible increase for breast cancer risk
• reduced pain threshold
• increased risk of fibromyalgia and chronic pain syndromes
• increased fracture risk
• possible increased risk of substance addiction, including alcoholism
• possible increased risk of Parkinson’s disease

Treatment options:

• Ensure adequate B6, B12, folate, magnesium, betaine, and methionine to support formation of SAM, Vitamin E