What is APOE?

A multifunctional lipid-transport protein with central roles in:

• lipid metabolism
• brain lipid transport
• glucose metabolism
• neuronal signaling
• neuronal inflammation
• mitochondrial function

Abnormal APOE associated with:

• increased risk of stroke
• hypertension
• heart attack
• increased risk of cognitive impairment
• may be an independent predictor of type 2 diabetes
• increased risk of low bone mass
• oxidative stress
• easier toxicity by heavy metals such as lead and mercury
• possible increased risk and disease severity of multiple sclerosis

Treatment options for abnormal APOE

• reduce stress
• reduce cardiovascular risk
• avoid smoking and minimize high-Glycemic foods
• moderate alcohol
• reduce excess weight
• fish oils
• physical activity
• fiber and antioxidants
• anti-inflammatory nutrition
• higher intake of DHA